Telomerase RNA Levels Limit the Telomere Length Equilibrium
نویسندگان
چکیده
منابع مشابه
Telomere length homeostasis requires that telomerase levels are limiting.
Stabilization of telomere length in germline and highly proliferative human cells is required for long-term survival and for the immortal phenotype of cancer-derived cells. This is achieved through expression of telomerase reverse transcriptase (TERT), which synthesizes telomeric repeats through reverse transcription of its tightly associated RNA template (TR). The telomeric repeat binding fact...
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Background Polycystic ovary syndrome (PCOS) is one of the reasons of infertility in women with chronic anovulation. Ovulation process is tightly regulated by molecular mechanisms controlling proliferation/differentiation of cells. Telomeres, TTAGGG tandem repeats, are transcribed into a non coding RNA, named TERRA. Recent studies suggest that TERRA sustain several important functions at chromos...
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introduction: the telomeric dna together with its associated proteins protects the chromosome ends from degradation or aberrant recombination. telomerase and telomere are closely associated with development of cancers. in this study we aim to investigate the significance of telomerase activity (ta) and telomere length (tl) in patients with acute promyelocytic leukemia (apl). methods: peripher...
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RNAs play important roles in cells. While much of the focus is on the precise mechanisms of RNA function, less attention has been focused on the importance of the level of specific functional RNAs. The RNA component of telomerase is essential for telomere maintenance. Recent experiments on the telomerase RNA have shown that changes in the level of this functional RNA have major consequences for...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Symposia on Quantitative Biology
سال: 2006
ISSN: 0091-7451,1943-4456
DOI: 10.1101/sqb.2006.71.063